Fetal Loss in Pregnant Rabbits Infected with Genotype 3 Hepatitis E Virus Is Associated with Altered Inflammatory Responses, Enhanced Virus Replication, and Extrahepatic Virus Dissemination with Positive Correlations with Increased Estradiol LevelArticle Published on 2023-04-252023-06-12 Journal: mBio [Category] E형 간염, Fulltext, [키워드] estradiol fetal loss Genotype 3 HEV Hepatitis E virus (HEV) Inflammatory cytokines Pregnancy rabbit HEV. [DOI] 10.1128/mbio.00418-23 PMC 바로가기
Discovery of benzimidazole substituted 1, 2, 4-oxadiazole compounds as novel anti-HBV agents with TLR8-agonistic activitiesArticle Published on 2022-12-152023-06-12 Journal: European journal of medicinal chemistry [Category] B형 간염, [키워드] 1,2,4-oxadiazole Anti-HBV benzimidazole Inflammatory cytokines TLR8 agonist. [DOI] 10.1016/j.ejmech.2022.114833 PMC 바로가기
A single-administration therapeutic interfering particle reduces SARS-CoV-2 viral shedding and pathogenesis in hamstersArticle Published on 2022-09-272022-11-15 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome Administered Antiviral effect coronavirus COVID-19 pandemic delta variant Detection limit disease dose effective Efficacy exhibited hamster hamsters highest Infectious virus Inflammatory cytokines Intervention intranasally intrinsically limit Lipid nanoparticle Lower mucosa nasal Particle Pathogenesis Postinfection Prevent reduce reduced reported respiratory tissue respiratory virus SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 transmission SARS-CoV-2 viral shedding severe disease severe lung pathology significantly lower suppress tested therapeutic therapeutic interfering particles TIP tissue Transmissibility Transmission uninfected variants variants. viral loads viral replication while [DOI] 10.1073/pnas.2204624119 PMC 바로가기
Diet-Induced Obesity and NASH Impair Disease Recovery in SARS-CoV-2-Infected Golden HamstersArticle Published on 2022-09-172022-11-15 Journal: Viruses [Category] SARS, 진단, [키워드] angiotensin-converting enzyme 2 Blood controls coronavirus disease Coronavirus disease 2019 COVID-19 days post-infection disease early stage Efficacy exhibited favor fibrosis form hamster hamsters hepatocyte ballooning impair induce infected with SARS-CoV-2 Infection Inflammation Inflammatory cytokines less liver Liver fibrosis liver steatosis long-lasting Lung inflammation lung viral load mechanism NASH non-alcoholic steatohepatitis obese obese patient obesity obesity. pathophysiologic Patient pulmonary fibrosis relative replicate SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected hamsters Serum level severity of COVID-19 steatohepatitis sustained systemic inflammation the SARS-CoV-2 Treatment weight loss [DOI] 10.3390/v14092067 PMC 바로가기
Partial carbonization of quercetin boosts the antiviral activity against H1N1 influenza A virusArticle Published on 2022-09-152023-06-23 Journal: Journal of Colloid and Interface Science [Category] 신종인플루엔자, [키워드] antioxidants Antiviral carbon nanomaterials Inflammatory cytokines phytochemicals Viral attachment. [DOI] 10.1016/j.jcis.2022.04.124 PMC 바로가기
Molecular mechanisms and therapeutic effects of different vitamins and minerals in COVID-19 patients코로나19 환자에서 다양한 비타민과 미네랄의 분자 기전과 치료 효과Review Published on 2022-09-012022-09-11 Journal: Journal of trace elements in medicine and biology [Category] 바이오마커, 변종, 유전자 메커니즘, 치료제, [키워드] activities addition Anti-inflammatory drugs antioxidant antioxidants Antiviral antiviral properties antiviral property boost component copper correlation COVID-19 COVID-19 patient COVID-19 patients Critical Critical illness cytokine release Cytokines disease Effect Factor Health high mortality immune function immune functions immune system Increased Infectious disease Inflammation Inflammatory cytokine Inflammatory cytokines iron lack manganese mechanism metabolic processe metabolic processes Micronutrient micronutrients mineral Minerals modulate mortality rate mortality rates oxidative stress Prevalence rapidly spreading disease reason remedy respiratory distress SARS-CoV-2 Selenium severe COVID-19 Severe respiratory distress Support therapeutic effect Trace element trace elements Treatment Vitamin vitamin A vitamins vitamins. Zinc [DOI] 10.1016/j.jtemb.2022.127044 PMC 바로가기 [Article Type] Review
The intersection molecule MDA5 in Cancer and COVID-19Article Published on 2022-08-312022-11-15 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 치료법, 치료제, [키워드] anti-tumor immunity antiviral response Autoimmune diseases cancer cell cGAS-STING connection COVID-19 cytoplasmic damaged dead Defense dsRNA evade function Host IFN immunomodulatory factor induce Inflammatory cytokines innate immune responses innate immune system interferon Intersection MDA5 mechanism Melanoma nucleic acid PAMPs pathogen-associated molecular pattern pattern recognition receptor Pattern recognition receptors pattern recognition receptors. PRRs recognizing RNA SARS-CoV-2 SARS-CoV-2 virus infection signaling pathway subsequent Trigger triggering Viral RNA virus [DOI] 10.3389/fimmu.2022.963051 PMC 바로가기
Nicotine in Combination with SARS-CoV-2 Affects Cells Viability, Inflammatory Response and Ultrastructural IntegritySARS-CoV-2와 결합된 니코틴은 세포 생존, 염증 반응 및 미세구조 완전성에 영향을 미칩니다Article Published on 2022-08-222022-09-12 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, [키워드] A549 A549 cell analyzed caused Cell cellular damage characterized chromatin Combination COVID-19 cytokine production Cytokines Cytopathic effect cytopathic effects cytoplasmic cytosol cytotoxicity decrease dose Endoplasmic reticulum expression level extracellular space feature granules human lung human lung adenocarcinoma A549 cells IL10 IL6 IL8 infected with SARS-CoV-2 Inflammatory cytokine Inflammatory cytokines integrity LPS mechanism of action membrane rupture Modification modifications modulate necroptosis Nicotine poly(I:C) positive proinflammatory proinflammatory cytokines protective role pyroptosis pyroptosis. response SARS-CoV-2 TNFα Vero E6 cell were used [DOI] 10.3390/ijms23169488 PMC 바로가기 [Article Type] Article
Epipharyngeal Abrasive Therapy (EAT) Reduces the mRNA Expression of Major Proinflammatory Cytokine IL-6 in Chronic EpipharyngitisEpipharyngeal Abrasive Therapy(EAT)는 만성 인두염에서 주요 전염증성 사이토카인 IL-6의 mRNA 발현을 감소시킵니다Article Published on 2022-08-162022-09-11 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, [키워드] Abrasive addition aggregation Alpha analyzed anti-inflammatory effect Cell chronic chronic fatigue syndrome chronic inflammation contribute cough COVID cytokine cytokine network Cytokines Diseases effective epipharyngeal abrasive therapy (EAT) epipharyngitis epipharynx expression expression pattern fatigue fatigue syndrome Hypothesis IgA IgA nephropathy IL-6 IL-6 expression IMPROVE In situ hybridization induce Inflammatory cytokine Inflammatory cytokines Inflammatory diseases interleukin interleukin 6 interleukin 6 (IL-6) intractable involved Japan Local Long Long COVID Major mechanisms mRNA myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) nasal Nasal cavity Necrosis nephropathy Patient postnasal drip Proinflammatory cytokine reduced reported responsible Sedation significantly lower subject suggested suppressed suppression Symptom syndrome systemic inflammatory disease systemic inflammatory diseases systemic symptoms therapy TNFα treated Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha tumor necrosis factor alpha (TNFα). upper respiratory tract [DOI] 10.3390/ijms23169205 PMC 바로가기 [Article Type] Article
Gasdermin D-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis Research Published on 2022-08-042022-10-05 Journal: The Pan African Medical Journal [Category] 변종, [키워드] Analysis contributed defined demonstrated DNA dysregulated exacerbate gasdermin D Genetic GSDMD implicated incidence Inflammation inflammatory cell Inflammatory cytokine Inflammatory cytokines mice mitochondrial NET Neutrophil extracellular trap oxidized Paquinimod pathology Patient pharmacological Platelet positive feedback loop promoted proteomic pyroptosis rapid clinical deterioration Sepsis Signaling significantly increased survival TLR4 toll-like receptor 4 triggering upregulation [DOI] 10.1038/s44161-022-00108-7 [Article Type] Research